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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0284-5 | 7 days | 5 µg | $120.00 |
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| CYK0284-20 | 7 days | 20 µg | $290.00 | |||
| CYK0284-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL 1RA Mouse, His |
|---|---|
| Description | |
| Interleukin-1 Receptor Antagonist Mouse Recombinant, His Tag | |
| Accession (Primary) | P25085 |
| Synonyms | |
| IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430. | |
| Introduction | |
| Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The IL 1RA was lyophilized from a 0.2 µm filtered concentrated solution in 1×PBS, pH 7.4, containing 1mM DTT. | |
| Stability | |
| Lyophilized IL 1RA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL 1RA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| HPLGKRPCRM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNT KLEEKIDVVP VEPHFVFLGI HGGKLCLSCV KSGDEMKLQL DAVNITDLRK NSEQDKRFTF IRSDSGPTTS FESAACPGWF LCTALEADQP VGLTNTPKAA VKVTKFYFQQ DQ | |
| Biological Activity | |
| The ED50 as determined by inhibiting IL-1a-dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 10 4 IU/mg in the presence of 75 pg/ml rPoIL-1a. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IL 1RA in sterile distilled H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 1RA Mouse, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P25085 ) | |
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ADMEbio Team
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ADMEbio Team
