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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0287-5 | 7 days | 5 µg | $120.00 |
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| CYK0287-20 | 7 days | 20 µg | $290.00 | |||
| CYK0287-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL 1RA Rat, His |
|---|---|
| Description | |
| Interleukin-1 Receptor Antagonist Rat Recombinant, His Tag | |
| Accession (Primary) | P25086 |
| Immunogen | |
| r.Human IL-2. | |
| Synonyms | |
| T-cell growth factor (TCGF), Interleukin-2, Lymphokine, IL-2. | |
| Introduction | |
| IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. | |
| Formulation | |
| 1mg/ml in PBS (after reconstitution). | |
| Solubility | |
| Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. | |
| Applications | |
| Direct ELISA, Western Blot, Immuneprecipitation, immunohistochemistry, blocking T cell poroliferation. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| YNRhIL2. | |
| Ig Subclass | |
| Mouse IgG2a. | |
| Purification Method | |
| Ion Exchange. | |
| Storage Procedures | |
| In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. | |
| Shipping Conditions | |
| Antibody is shipped lyophilized at ambient temperature. | |
| Titer | |
| By direct ELISA: 1:10,000 dilution will yield 0.4 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories). 1:50 dilution will block 70-80% of CTLL proliferative response to 50 units of r.human IL-2. | |
| Cross reactivity | |
| A certain degree of functional cross reactivity with murine IL-2 was reported by some investigators. | |
| Precautions | |
| IL 1RA Rat, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P25086 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
