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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0290-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| CYK0290-10 | 7 days | 10 µg | $290.00 | |||
| CYK0290-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | IL 2 Human, His |
|---|---|
| Description | |
| Interleukin-2 Human Recombinant, His Tag | |
| Accession (Primary) | P60568 |
| Synonyms | |
| Interleukin-2, T-cell growth factor (TCGF), Interleukin-2, Lymphokine, IL-2. | |
| Introduction | |
| IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. | |
| Source | |
| Pichia pastoris. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a 0.2 µm filtered solution in 20mM sodium phosphate buffer pH 7.0 in absence of any carrier protein. | |
| Stability | |
| Lyophilized Interleukin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Interleukin-2 should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| A P T S S S T K K T Q L Q L E H L L L D L Q M I L N G I N N Y K N P K L T R M L T F K F Y M P K K A T E L K H L Q C L E E E L K P L E E V L N L A Q S K N F H L R P R D L I S N I N V I V L E L K G S E T T F M C E Y A D E T A T I V E F L N R W I T F C Q S I I S T L T. | |
| Biological Activity | |
| The biological activity is determined by the dose dependent proliferation of mouse CTLL–2 cells. Optimal concentration for individual application should be determined by a dose response assay. ED50 range = 0.08–0.5ng/ml | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin-2 in sterile 18M-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 2 Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P60568 ) | |
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ADMEbio Team
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