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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0294-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0294-20 | 7 days | 20 µg | $290.00 | |||
| CYK0294-1 | 7 days | 1 mg | $4,032.00 |
Product Overview | |
| Name | IL 2 Rat |
|---|---|
| Description | |
| Interleukin-2 Rat Recombinant | |
| Accession (Primary) | P17108 |
| Synonyms | |
| IL10D, ZCYTO10, IL-20, MGC96907, Four alpha helix cytokine Zcyto10. | |
| Introduction | |
| IL20 is a cytokine structurally related to interleukin 10 (IL10). IL20 cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized carrier free. | |
| Stability | |
| Lyophilized Interleukin-20 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL20 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Lys-Thr-Leu. | |
| Biological Activity | |
| The Biological Activity was determined by measuring the dose dependent activation of STAT3 in human epidermal keratinocytes (HEKa cells).Significant STAT3 activation is observed with 100 ng/mL of recombinant human IL-20 corresponding to a Specific Activity of 10,000IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin -20 in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml or less. | |
| Precautions | |
| IL 2 Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P17108 ) | |
References |
Title :Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells. Publication :The Journal of Immunology June 1, 2007 vol. 178 no. 11 6949-6957 Link : IL 2 Rat prospec publication |
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ADMEbio Team
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ADMEbio Team
