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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0297-2 | 7 days | 2 µg | $120.00 |
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| CYK0297-10 | 7 days | 10 µg | $290.00 | |||
| CYK0297-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | IL 21 Human |
|---|---|
| Description | |
| Interleukin-21 Human Recombinant | |
| Accession (Primary) | Q9HBE4 |
| Synonyms | |
| Interleukin-21, IL-21, Il21. | |
| Introduction | |
| IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Mouse IL-21 was lyophilized from 20mM NaHCO3, pH 8.5. | |
| Stability | |
| Lyophilized Mouse IL-21 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse IL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and was found to be Met-His-Lys-Ser-Ser. | |
| Biological Activity | |
| The ED50=10 -50 ng/ml, determined by the cell proliferation assay of modified Ba/F3 cells. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Mouse IL21 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 21 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9HBE4 ) | |
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ADMEbio Team
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