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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0315-2 | 7 days | 2 µg | $120.00 |
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| CYK0315-10 | 7 days | 10 µg | $290.00 | |||
| CYK0315-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL 3 Human |
|---|---|
| Description | |
| Interleukin-3 Human Recombinant | |
| Accession (Primary) | P08700 |
| Synonyms | |
| MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399. | |
| Introduction | |
| Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| Interleukin-3 His (1mg/ml) is supplied in 20mM Tris-HCl buffer (pH 8.0), 0.2mM PMSF and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MAPMTQTTSL KTSWVNCSNM IDEIITHLKQ PPLPLLDFNN LNGEDQDILM ENNLRRPNLE AFNRAVKSLQ NASAIESILK NLLPCLPLAT AAPTRHPIHI KDGDWNEFRR KLTFYLKTLE NAQAQQTTLS LAIF. | |
| Biological Activity | |
| The ED50 for this effect is <0.53ng/ml. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. | |
| Precautions | |
| IL 3 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P08700 ) | |
References |
1. Title :Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. Publication :Published online before print March 30, 2010, doi: 10.1096/fj.09-148155 August 2010 The FASEB Journal vol. 24 no. 8 2869-2880 . Link : IL 3 prospec publication 2. Title :A Method for the Selection of Human Embryonic Stem Cell Sublines with High Replating Efficiency After Single-Cell Dissociation. Publication :Article first published online: 24 AUG 2006 DOI:10.1634/stemcells.2005-0657 Copyright © 2006 AlphaMed Press Link : IL 3 Human prospec publication 3. Title: Selective Activation of Human Dendritic Cells by OM-85 through a NF-kB and MAPK Dependent Pathway Publications: PloS one 8.12 (2013): e82867 Link: Interleukin-3 prospec publication 4. Title: Novel markers of normal and neoplastic human plasmacytoid dendritic cells Publication: Blood 111.7 (2008): 3778-3792. Link: Interleukin-3 Human prospec publication |
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ADMEbio Team
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