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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0318-2 | 7 days | 2 µg | $120.00 |
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| CYK0318-10 | 7 days | 10 µg | $290.00 | |||
| CYK0318-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL 3 Mouse |
|---|---|
| Description | |
| Interleukin-3 Mouse Recombinant | |
| Accession (Primary) | P01586 |
| Synonyms | |
| MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399. | |
| Introduction | |
| Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Interleukin-3 Rat was lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4. | |
| Stability | |
| Lyophilized Interleukin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC. | |
| Biological Activity | |
| The ED 50 as determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is < 10 ng/ml, corresponding to a specific activity of >1.0 x 10 5 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin 3 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 3 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P01586 ) | |
References |
1. Title : Direct binding of Cbl to Y568 and Y936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Publication :Biochemical Journal Immediate Publication. Published on 19 Jun 2006 as manuscript BJ20060464. Link : IL 3 Mouse prospec publication 2. Title :enhanced self -renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene sall4. Publication : Link : Interleukin-3 Mouse prospec publication 3 . Title :Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Publication :Published online before printMay 9, 2006, doi:10.1182/blood-2005-07-008896 Submitted: July 14, 2005Accepted: April 26, 2006 Blood September 1, 2006vol. 108no. 51542-1550. Link : http://bloodjournal.hematologylibrary.org/content/108 /5/1542.full |
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