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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0332-2 | 7 days | 2 µg | $120.00 |
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| CYK0332-10 | 7 days | 10 µg | $290.00 | |||
| CYK0332-1 | 7 days | 1 mg | $6,240.00 |
Product Overview | |
| Name | IL 4 Human, Yeast |
|---|---|
| Description | |
| Interleukin 4 Human Recombinant, Yeast | |
| Accession (Primary) | P05112 |
| Synonyms | |
| BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra. | |
| Introduction | |
| Interleukin-4 is a pleiotropic cytokine produced primarily by activated T lymphocytes, basophils and mast cells. Multiple immune response-modulating functions are performed by IL-4 on a variety of cell types and it has an important role in the regulator of isotype switching, induction of IgE production in B lymphocytes and differentiation of precursor T helper cells. IL-4 binds to both membrane-bound and secreted soluble IL-4 receptors. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm concentrated (1mg/ml) solution in PBS pH 7.4. | |
| Stability | |
| Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S. | |
| Biological Activity | |
| The ED 50 as determined by the dose-dependant induction of HT-2 cell proliferation is less than 2 ng/ml corresponding to a Specific Activity of 500,000IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin 4 in sterile 10mM HAc not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title: CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. publication : Published online before printJune 27, 2005, doi: 10.1073/pnas.0501050102 PNAS July 5, 2005vol. 102no. 279583-9588. Link: IL 4 Mouse prospec publication | |
| Precautions | |
| IL 4 Human, Yeast is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P05112 ) | |
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