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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0346-2 | 7 days | 2 µg | $120.00 |
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| CYK0346-10 | 7 days | 10 µg | $290.00 | |||
| CYK0346-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | IL 7 Human |
|---|---|
| Description | |
| Interleukin-7 Human Recombinant | |
| Accession (Primary) | P13232 |
| Synonyms | |
| Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. | |
| Introduction | |
| IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. | |
| Source | |
| HEK. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The IL7 was lyophilized from 1mg/ml in 1xPBS. | |
| Stability | |
| Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as obsereved by SDS-PAGE. | |
| Biological Activity | |
| The activity was determined by the dose dependent stimulation of the proliferation of murine 2E8 cells and is typically 0.3ng/ml corresponding to a specific activity of 3,333,334units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IL-7 in sterile PBS containing 0.1% endotoxin-free recombinant HSA. | |
| Precautions | |
| IL 7 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P13232 ) | |
References |
Title: Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer Publication: Gene therapy 16.5 (2009): 596-604. Link: IL 7 Human prospec publication |
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