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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0350-2 | 7 days | 2 µg | $120.00 |
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| CYK0350-10 | 7 days | 10 µg | $290.00 | |||
| CYK0350-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | IL 7 Mouse |
|---|---|
| Description | |
| Interleukin-7 Mouse Recombinant | |
| Accession (Primary) | P10168 |
| Synonyms | |
| Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. | |
| Introduction | |
| IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4. | |
| Stability | |
| Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-7 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| DCHIKDKDGK AFGSVLMISI NQLDKMTGTD SDCPNNEPNF FKKHLCDDTK EAAFLNRAAR KLRQFLKMNI SEEFNDHLLR VSDGTQTLVN CTSKEEKTIK EQKKNDPCFL KRLLREIKTC WNKILKGSI | |
| Biological Activity | |
| The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2ng/ml, corresponding to a specific activity of > 5,000,000IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IL-7 in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 7 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P10168 ) | |
References |
Title: Disruption of Bis Leads to the Deterioration of the Vascular Niche for Hematopoietic Stem Cells Publication: Stem Cells 28.2 (2010): 268-278. Link: IL 7 Mouse prospec publication |
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ADMEbio Team
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