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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0357-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| CYK0357-10 | 7 days | 10 µg | $290.00 | |||
| CYK0357-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | IL10 Human |
|---|---|
| Description | |
| Interleukin-10 Human Recombinant | |
| Accession (Primary) | P22301 |
| Synonyms | |
| Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10, GVHDS, IL10A, TGIF, T-Cell Growth Inhibitory Factor. | |
| Introduction | |
| Interleukin 10 or IL-10 or human cytokine synthesis inhibitory factor, is a cytokine (anti-inflammatory). IL10 gene is coding for il-10 In humans. Interleukin 10 has a receptor complex that is built from a couple of IL-10 receptor-1 and a couple of IL-10 receptor-2 proteins. therfore, the whole receptor unit consists of four IL-10 receptor molecules. IL-10 binds the receptor and causes STAT3 signalling through the phosphorylation of the cytoplasmic ends of IL-10 receptor 1 and IL-10 receptor 2 through JAK1 and Tyk2. | |
| Source | |
| Sf9, Baculovirus cells. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The IL-10 solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN HHHHHH . | |
| Biological Activity | |
| Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 range < 5 ng/ml. | |
| Precautions | |
| IL10 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P22301 ) | |
References |
1. Title :Activated signal transducer and activator of transcription-3 (STAT3) is a poor regulator of tumour necrosis factor- production by human monocytes. Publication :Article first published online: 9 JAN 2007 DOI:10.1111/j.1365-2249.2006.03291.x Link : IL10 prospec publication 2. Title :Suppressor of cytokine signalling-3 at pathological levels does not regulate lipopolysaccharide or interleukin-10 control of tumour necrosis factor-? production by human monocytes. Publication :Article first published online: 11 MAY 2006 DOI: 10.1111/j.1365-2567.2006.02383.x Link : IL10 Human prospec publication 3. Title :The Tyrosine Sulfate-rich Domains of the LRR Proteins Fibromodulin and Osteoadherin Bind Motifs of Basic Clusters in a Variety of HPR-binding Proteins, Including Bioactive Factors*. Publication :First Published on August 21, 2009, doi: 10.1074/jbc.M109.047076 October 16, 2009 The Journal of Biological Chemistry, 284, 28543-28553. Link : Interleukin-10 prospec publication |
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ADMEbio Team
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