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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0380-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0380-25 | 7 days | 25 µg | $290.00 | |||
| CYK0380-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL17D Human |
|---|---|
| Description | |
| Interleukin-17D Human Recombinant | |
| Accession (Primary) | Q8TAD2 |
| Immunogen | |
| r.Human IL-17E | |
| Synonyms | |
| IL-25, IL-17E, IL17E, IL25, Interleukin-25. | |
| Introduction | |
| IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn’t induce allergic inflammation in vivo. | |
| Formulation | |
| 1mg/ml in PBS (after reconstitution). | |
| Solubility | |
| Reconstitute with H 2 0. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. | |
| Applications | |
| Direct ELISA, Immuneprecipitation, immunohistochemistry. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| YR-hIL17E. | |
| Ig Subclass | |
| mouse IgG2a. | |
| Purification Method | |
| Protein A. | |
| Storage Procedures | |
| In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. | |
| Shipping Conditions | |
| Antibody is shipped lyophilized at ambient temperature. | |
| Titer | |
| By direct ELISA, 1:10,000 dilution will yield >1.0 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories). | |
| Precautions | |
| IL17D Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8TAD2 ) | |
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ADMEbio Team
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ADMEbio Team
