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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0403-2 | 7 days | 2 µg | $120.00 |
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| CYK0403-10 | 7 days | 10 µg | $290.00 | |||
| CYK0403-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | IL1R1 Human |
|---|---|
| Description | |
| Interleukin 1 Receptor Type I Human Recombinant | |
| Accession (Primary) | P14778 |
| Synonyms | |
| IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, IL-1 type II receptor, Interleukin-1 receptor beta, CD121 antigen-like family member B. | |
| Introduction | |
| IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. IL1R2 is expressed mainly by T cells, endothelial cells and fibroblasts. IL1R2 binds IL1A, IL1B and IL1RN preventing them from binding to their regular receptors and thus inhibiting the transduction of their signaling. Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. | |
| Source | |
| Sf9, Insect cells. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| IL1R2 protein solution (0.5mg/ml) contains PBS (pH7.4) and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE LEHHHHHH . | |
| Biological Activity | |
| Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is ≤ to 400 ng/ml with IL-1beta. | |
| Precautions | |
| IL1R1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P14778 ) | |
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