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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0454-3 | 7 days | 3 µg | $120.00 |
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| CYK0454-15 | 7 days | 15 µg | $290.00 | |||
| CYK0454-0.1 | 7 days | 0.1 mg | $1,440.00 |
Product Overview | |
| Name | IL4R Human |
|---|---|
| Description | |
| Interleukin-4 Receptor Human Recombinant | |
| Accession (Primary) | P24394 |
| Synonyms | |
| Interleukin-5, IL-5, EDF, TRF, Eosinophil differentiation factor, T-cell replacing factor. | |
| Introduction | |
| The protein encoded by IL5is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of IL5is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). Interleukin-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. Interleukin-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. | |
| Source | |
| Sf9, Baculovirus cells . | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The IL5 solution (0.25mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| VENPMNRLVA ETLTLLSTHR TWLIGDGNLM IPTPENKNHQ LCIKEVFQGI DTLKNQTAHG EAVDKLFQNL SLIKEHIERQ KKRCAGERWR VTKFLDYLQV FLGVINTEWT PES HHHHHH | |
| Biological Activity | |
| Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 15 ng/ml. | |
| Precautions | |
| IL4R Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P24394 ) | |
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ADMEbio Team
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