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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0470-5 | 7 days | 5 µg | $120.00 |
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| CYK0470-20 | 7 days | 20 µg | $290.00 | |||
| CYK0470-1 | 7 days | 1 mg | $5,760.00 |
Product Overview | |
| Name | IRF 2 Human |
|---|---|
| Description | |
| IFN Regulatory Factor-2 Human Recombinant | |
| Accession (Primary) | P14316 |
| Synonyms | |
| IRF-3, IRF3, IFN Regulatory Factor 3. | |
| Introduction | |
| Members of the IFN regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates IFN-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| 1mg/ml in phosphate-buffered saline (PBS), pH 7.4. | |
| Stability | |
| Liquid IRF3 although stable at 10°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS. | |
| Precautions | |
| IRF 2 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P14316 ) | |
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ADMEbio Team
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