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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0473-5 | 7 days | 5 µg | $120.00 |
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| CYK0473-20 | 7 days | 20 µg | $290.00 | |||
| CYK0473-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IRF1 Human |
|---|---|
| Description | |
| IFN Regulatory Factor-1 Human Recombinant | |
| Accession (Primary) | P10914 |
| Immunogen | |
| Anti-human IRF3 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IRF3 amino acids 108-166 purified from E. coli. | |
| Synonyms | |
| IRF-3, IRF3, Interferon Regulatory Factor 3. | |
| Introduction | |
| Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. | |
| Applications | |
| IRF3 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| P3F10AT. | |
| Ig Subclass | |
| Mouse IgG1 heavy chain and κ light chain. | |
| Purification Method | |
| IRF3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| IRF1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P10914 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
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ADMEbio Team
