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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0499-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0499-25 | 7 days | 25 µg | $290.00 | |||
| CYK0499-1 | 7 days | 1 mg | $4,640.00 |
Product Overview | |
| Name | RELM a Mouse, His |
|---|---|
| Description | |
| RELM-Alpha Mouse Recombinant, His Tag | |
| Accession (Primary) | Q9EP95 |
| Synonyms | |
| Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2. | |
| Introduction | |
| RELM-beta (Resistin-Like Molecule-beta) is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin (also called FIZZ3), RELM-alfa (FIZZ1), RELM-beta (FIZZ2) and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents. RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant. The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| RELM-b was lyophilized from a solution containing 0.1% Trifluoroacetic Acid (TFA). | |
| Stability | |
| Lyophilized RELM-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution RELM-b Human Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MQCSLDSVMD KKIKDVLNSL EYSPSPISKK LSCASVKSQG RPSSCPAGMA VTGCACGYGC GSWDVQLETT CHCQCSVVDW TTARCCHLT. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized RELM-b in sterile 0.1% TFA not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| RELM a Mouse, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9EP95 ) | |
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ADMEbio Team
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ADMEbio Team
