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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0501-5 | 7 days | 5 µg | $120.00 |
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| CYK0501-25 | 7 days | 25 µg | $290.00 | |||
| CYK0501-1 | 7 days | 1 mg | $4,640.00 |
Product Overview | |
| Name | RELM b Human, His |
|---|---|
| Description | |
| RELM-Beta Human Recombinant, His Tag | |
| Accession (Primary) | Q9BQ08 |
| Synonyms | |
| Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2. | |
| Introduction | |
| RELM-beta (Resistin-Like Molecule-beta) is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin (also called FIZZ3), RELM-alfa (FIZZ1), RELM-beta (FIZZ2) and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents. RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant. The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Brownish lyophilized powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (1mg/ml) protein solution containing 10mM Acetic Acid with 2:1 mannitol to protein. | |
| Stability | |
| Lyophilized RETNLB is stable at -20°C. After reconstitution the protein should be kept at all times at -20°C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage. | |
| Purity | |
| Greater than 97% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA. | |
| Solubility | |
| Reconstitute at 0.1 mg/ml with sterile pyrogen free water. | |
| Precautions | |
| RELM b Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9BQ08 ) | |
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ADMEbio Team
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ADMEbio Team
