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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0608-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| CYK0608-10 | 7 days | 10 µg | $290.00 | |||
| CYK0608-1 | 7 days | 1 mg | $6,192.00 |
Product Overview | |
| Name | TPO Mouse |
|---|---|
| Description | |
| Thrombopoietin Mouse Recombinant | |
| Accession (Primary) | P40226 |
| Synonyms | |
| Thpo, C-mpl ligand,ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, Mgdf, Ml, Mpllg, Tpo, thrombopoietin isoform 1. | |
| Introduction | |
| Thrombopoietin or TPO or MGDF, is a protein (glycoprotein hormone) that can be found in the liver and kidney tissues. TPO regulates the creation of platelets. The protein enhances the production & differentiation of cells such as megakaryocytes that are part of the bone marrow cells that secretes a wide number of platelets. The cellular development process that ends up in the production of platelet calls (Megakaryocytopoiesis). Humoral growth factor is needed for the megakaryocyte proliferation & maturation of megakaryocyte, not apart from thrombopoiesis. | |
| Source | |
| HEK293 . | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| TPO protein (0.5mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range ≤4ng/ml. | |
| Amino acid sequence | |
| SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSR LQGFRVKITP GQLNQTSRSP VQISGYLNRT HGPVNGTHGL FAGTSLQTLE ASDISPGAFN KGSLAFNLQG GLPPSPSLAP DGHTPFPPSP ALPTTHGSPP QLHPLFPDPS TTMPNSTAPH PVTMYPHPRN LSQET HHHHH H. | |
| Biological Activity | |
| Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is ≥ 25ug/ml. | |
| Precautions | |
| TPO Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P40226 ) | |
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ADMEbio Team
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