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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0622-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0622-25 | 7 days | 25 µg | $290.00 | |||
| CYK0622-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | Visfatin Human |
|---|---|
| Description | |
| Visfatin Human Recombinant | |
| Accession (Primary) | P43490 |
| Synonyms | |
| PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik. | |
| Introduction | |
| Excess adiposity is the most important risk in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Adipose tissue produces several proteins (adipocytokines) such as leptin, adiponectin, resistin, tumor necrosis factor-?, and IL-6, that modulate insulin sensitivity and appear to play an important role in the pathogenesis of insulin resistance, diabetes, dyslipidemia, inflammation, and atherosclerosis. However, the mechanisms by which fat tissue induces insulin resistance and the role of adipocytokines in the pathogenesis of T2DM have not been well established. Visfatin, also known as pre-B cell colony-enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks, and bacteria, as well as in vertebrates, including humans and the mouse. It has been postulated to play a role in innate immunity. Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion. In keeping with its insulin-mimetic effects, visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin did not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different regions of the receptor. Thus, visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction, and might contribute to the pathogenesis of diabetes. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered solution at a concentration of 1mg/ml. | |
| Formulation | |
| Visfatin His tag protein contains 20mM Tris pH-8, 0.1mM DTT & 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK CSYVVTNGLG INVFKDPVAD PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA QLNIELEAAH H. | |
| Precautions | |
| Visfatin Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P43490 ) | |
Background |
About Visfatin Human Visfatin is a cytokine expressed in visceral fat that was originally isolated as a secreted element that synergized with stem cell factors and IL-7. One of its main functions is to enhance the development of B cell precursors. The cytokine is also known as the “Pre-B Cell Colony-Enhancing Factor (PBEF).” It has been identified in vertebrates, including mice and humans, and it’s being studied due to its link to inflammatory conditions, beta cell function, and cardiovascular disease. What’s the Function of Visfatin Human Recombinant? Visfatin human recombinant is produced in E. Coli. It’s a single, non-glycosylated, polypeptide chain that contains 466 amino acids, it’s purified by FLAG-affinity chromatography, and it contains a total molecular mass of 52.6 kDa. What Are the Main Applications of Visfatin Human Recombinant? The cytokine is being researched because of its involvement in glucose homeostasis, dysregulation in biosynthesis and signal transduction, and the pathogenesis of diabetes. Visfatin human recombinant is tailored exclusively for laboratory research, ensuring experts can get further answers regarding the cytokine’s involvement in different processes, including pathogenesis, diabetes, inflammation, dyslipidemia, and atherosclerosis. Findings can also help during the identification of high-risk people for cardiovascular disease and diabetes. |
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