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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0634-2 | 7 days | 2 µg | $100.00 |
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|
Product Overview | |
| Name | BMP 7 Human, CHO |
|---|---|
| Description | |
| Bone Morphogenetic Protein-7 Human Recombinant, CHO | |
| Accession (Primary) | P18075 |
| Synonyms | |
| Bone morphogenetic protein 10, BMP-10. | |
| Introduction | |
| Bone Morphogenetic protein-10 also known as BMP-10 takes an important part in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. BMP-10 signals through numerous receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors induces signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. | |
| Source | |
| HEK. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The BMP10 protein was lyophilized from 10mM Sodium Citrate, pH 2.7 and 75mM NaCl . | |
| Stability | |
| Lyophilized BMP10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by analysis by SDS-PAGE and HPLC analysis. | |
| Amino acid sequence | |
| NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR. | |
| Biological Activity | |
| The specific activity was determined by its ability to induce alkaline phosphatase production in the ATDC-5 cell line and is typically 4.0-6.0 ng/ml ED50. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized BMP10 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| BMP 7 Human, CHO is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P18075 ) | |
References |
1. Title :Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis. Publication :Article first published online: 30 JUL 2009 DOI:10.1111/j.1349-7006.2009.01301.x © 2009 Japanese Cancer Association. Link : http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2009.01301.x/full 2. Title :In Vivo Degradation of a Novel Poly(?-Caprolactone) Invertebral Cage for Anterior Cervical Discectomy and Fusion in a Porcine Model. Publication :Tissue Engineering and Regenerative Medicine International Society – EU Meeting -2010Galway, Ireland Link : http://64.130.18.83/docs/eu10_abstracts/TERMIS2010_0708.pdf 3. Title: Pretreatment With Bone Morphogenetic Protein-7 (Bmp-7) Mimics Ischemia Preconditioning Following Intestinal Ischemia/Reperfusion Injury in the Intestine and Liver. Publication :November 2008 - Volume 30 - Issue 5 - pp 532-536 doi: 10.1097/SHK.0b013e31816f20f1 Basic Science Aspects. Link : http://journals.lww.com/shockjournal/Abstract/2008/ 11000/Pretreatment_With_Bone_Morphogenetic_Protein_7.8.aspx |
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