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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0642-1 | 7 days | 1 µg | $100.00 |
Select product before adding to cart
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| CYK0642-5 | 7 days | 5 µg | $260.00 | |||
| CYK0642-100 | 7 days | 100 µg | $2,400.00 |
Product Overview | |
| Name | IL 12 p40 Human, Plant |
|---|---|
| Description | |
| Interleukin-12 p40 Human Recombinant, Plant | |
| Accession (Primary) | P29460 |
| Synonyms | |
| NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12. | |
| Introduction | |
| IL-12 is a heterodimeric cytokine that stimulates the production of IFN gamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells. It is an initiator of cell-mediated immunity. | |
| Source | |
| Baculovirus. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein (1mg/ml) was lyophilized with no additives. | |
| Stability | |
| Lyophilized Interleukin-12 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL12 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and found to be Arg-Val-Ile-Pro-Val at the p35 subunit and Met-Thr-Glu-Leu-Glu at the p40 subunit. | |
| Biological Activity | |
| ED50 range = 0.01-0.05 ng/ml corresponding to a specific activity of 20,000,000-100,000,000IU/mg as determined by the dose dependent secretion of IFN-gamma from PHA and IL-2 activated mouse splenocytes that have been costimulated with PMA. Optimal concentration for individual application should be determined by a dose response assay. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin 12 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 12 p40 Human, Plant is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P29460 ) | |
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ADMEbio Team
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