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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0645-2 | 7 days | 2 µg | $100.00 |
Select product before adding to cart
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| CYK0645-10 | 7 days | 10 µg | $260.00 | |||
| CYK0645-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | IL 17 Human, HEK |
|---|---|
| Description | |
| Interleukin-17 Human Recombinant, HEK | |
| Accession (Primary) | Q16552 |
| Synonyms | |
| Cytokine ML-1, IL-17F, Interleukin-17F precursor, IL17F, ML1, ML-1. | |
| Introduction | |
| IL-17F having an accession number of Q96PD4 is a cytokine that shares sequence similarity with IL17. IL-17F is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. IL-17F inhibits the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. IL-17F induces stromal cells to produce proinflammatory and hematopoietic cytokines. Intestinal IL17F gene expression is increased in active CD. IL-17A & IL-17F alleles influence the susceptibility to and pathophysiological features of ulcerative colitis independently. IL-17F and MIF gene polymorphisms are significantly associated with the development of functional dyspepsia. The initiation of IL-17F/IL-17R signaling pathway requires the receptor ubiquitination by TRAF6. IL-17F induces expression of IFN-gamma-inducible protein 10 (IP-10) by activating Raf1-mitogen-activated protein kinase 1/2-extracellular-regulated kinase 1/2-p90 ribosomal S6 kinase-cyclic AMP response element-binding protein signaling pathway. | |
| Source | |
| HEK. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The IL17F was lyophilized from 1mg/ml in 1xPBS. | |
| Stability | |
| Lyophilized IL-17F although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17F should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as obsereved by SDS-PAGE. | |
| Biological Activity | |
| The specific activity was determined by the dose-dependent induction of IL-6 secretion from NHDF Adult fibroblasts, and is typically 100-500ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IL-17F in sterile water not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 17 Human, HEK is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q16552 ) | |
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