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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0658-2 | 7 days | 2 µg | $100.00 |
Select product before adding to cart
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| CYK0658-10 | 7 days | 10 µg | $260.00 | |||
| CYK0658-100 | 7 days | 100 µg | $1,760.00 |
Product Overview | |
| Name | IL 9 Human, HEK |
|---|---|
| Description | |
| Interleukin-9 Human Recombinant, HEK | |
| Accession (Primary) | P15248 |
| Synonyms | |
| IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23. | |
| Introduction | |
| IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| IL-22 Antagonist Mouse is lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3. | |
| Stability | |
| Lyophilized Interleukin-22 Mouse Antagonist although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL22 Antagonist should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by: (a) Gel filtration chromatography under non-denaturing conditions. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Pro-Val-Asn. | |
| Biological Activity | |
| IL-22 E117A mutant is capable of full inhibition of STAT3 phosphorylation induced by mouse interleukin 22 in HepG cells. Its affinity toward immobilized mIL-22 receptor a1 extracellular domain (mIL-22 Ra1-ECD) or IL-22 binding protein is similar to the non-mutated mouse interleukin 22. Mouse IL-22 antagonist (E117A) has very low agonistic activity in this bioassay. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 9 Human, HEK is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P15248 ) | |
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