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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4157-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4157-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Cyclin H (4E11) Mouse mAb |
|---|---|
| Accession (Primary) | P51946 |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Species Reactivity | |
| Reacts With | Human |
| Calculated MW | |
| Calculated MW: 38 kDa; Observed MW: 38 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000; IP-1:20 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. | |
Target Information: ( P51946 ) | |
| Name | CCNH |
| Gene ID | 902 |
| Other Names | |
| CCNH; Cyclin-H; MO15-associated protein; p34; p37; CAK; CycH; Cyclin H | |
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ADMEbio Team
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