Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0800-200 | 7 days | 200I µ | $1,080.00 |
Select product before adding to cart
|
||
| RCP0800-400 | 7 days | 400I µ | $1,960.00 | |||
| RCP0800-600 | 7 days | 600I µ | $2,160.00 |
Product Overview | |
| Name | F8 Human |
|---|---|
| Description | |
| Coagulation Factor-VIII Human | |
| Accession (Primary) | P00451 |
| Synonyms | |
| Coagulation factor VIII, Procoagulant component, Antihemophilic factor, AHF, F8, F8C, F8B, HEMA, FVIII, DXS1253E, F8 protein. | |
| Introduction | |
| Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. | |
| Source | |
| CHO cells (Chinese Hamster Ovarian Cells). | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Each 250IU vial was lyophilized from a solution containing 8mg Tween-80, 112mM NaCl, 40mg Mannitol, 10mg Trehalose, 1ng VWF and 4.2mM CaCl2. | |
| Stability | |
| Lyophilized Factor-VIII although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIII should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by SDS-PAGE. | |
| Biological Activity | |
| The specific activity was found to be 7,058 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute 250IU lyophilized Factor-VIII in 5ml sterile 18M-cm H 2 O, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| F8 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P00451 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
