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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0017-2 | 7 days | 2 µg | $120.00 |
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| GRF0017-10 | 7 days | 10 µg | $290.00 | |||
| GRF0017-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | CSF2RB Human |
|---|---|
| Description | |
| GM-CSF Receptor Beta Human Recombinant | |
| Accession (Primary) | P32927 |
| Immunogen | |
| Anti-human CSK mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CSK amino acids 1-450 purified from E. coli. | |
| Synonyms | |
| Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK, C-Src Tyrosine Kinase. | |
| Introduction | |
| C-Src Tyrosine Kinase, also known as CSK, regulates cell growth, migration, differentiation, and immune response. CSK Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases. CSK is a protein coding gene which suppresses signaling by several surface receptors. Among CSK's related pathways are PI-3K cascade and Signaling by FGFR. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide. | |
| Applications | |
| CSK antibody has been tested by ELISA, Western blot analysis and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| PAT7C6AT. | |
| Ig Subclass | |
| Mouse IgG 2b heavy chain and κ light chain. | |
| Purification Method | |
| CSK antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| CSF2RB Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P32927 ) | |
Background |
Title: GM-CSF Receptor Beta Human Recombinant: A Key Receptor in Immunological Research Abstract: Granulocyte-macrophage colony-stimulating factor receptor beta (GM-CSF Rβ) is a crucial receptor involved in immune cell development and function. This research paper provides a comprehensive analysis of human recombinant GM-CSF Rβ, focusing on its production, characterization, and applications in immunological research. The paper discusses the significance of GM-CSF Rβ in immune cell signaling and its role in various immune-related disorders. Furthermore, it elucidates the potential therapeutic implications of recombinant GM-CSF Rβ in immunotherapy and highlights ongoing research in the field. The information presented in this paper aims to enhance the understanding of human recombinant GM-CSF Rβ and its utility as a research tool in immunological studies. Introduction: Granulocyte-macrophage colony-stimulating factor receptor beta (GM-CSF Rβ) is a high-affinity receptor that binds to granulocyte-macrophage colony-stimulating factor (GM-CSF). It plays a critical role in immune cell development, differentiation, and activation. Human recombinant GM-CSF Rβ, produced through genetic engineering techniques, enables researchers to investigate its biological functions and therapeutic potential. Production and Characterization: Recombinant GM-CSF Rβ is typically produced using expression systems such as mammalian cells or bacteria. The protein is then purified and characterized to ensure its structural integrity and functional activity. Quality control measures are implemented to confirm the specificity and binding affinity of the recombinant receptor. Immunological Significance: GM-CSF Rβ is expressed on various immune cells, including myeloid cells, dendritic cells, and macrophages. It plays a crucial role in cell signaling pathways, promoting cell proliferation, survival, and activation. The dysregulation of GM-CSF Rβ signaling has been implicated in autoimmune diseases, inflammatory disorders, and hematological malignancies. Recombinant GM-CSF Rβ provides a valuable tool for investigating these immune-related processes and deciphering the underlying mechanisms. Therapeutic Implications: The dysregulation of GM-CSF Rβ signaling in immune-related disorders has prompted the exploration of recombinant GM-CSF Rβ as a potential therapeutic target. Targeted therapies, such as monoclonal antibodies and small-molecule inhibitors, are being developed to modulate GM-CSF Rβ signaling and restore immune homeostasis. Ongoing research focuses on optimizing these therapeutic approaches and identifying novel treatment strategies. Conclusion: Human recombinant GM-CSF Rβ is a critical research tool in the field of immunology. Its production, characterization, and applications in immune cell signaling contribute to our understanding of immune responses and the development of novel therapeutics. Continued research and advancements in GM-CSF Rβ-based immunotherapy hold promise for improving treatment outcomes in various immune-related disorders. |
References |
Bibliography: Hamilton, J. A. (2008). GM-CSF signaling in macrophages: Insights from gene expression analysis. Immunobiology, 214(9-10), 683-693. Hamilton, J. A. (2019). GM-CSF in inflammation. Journal of Experimental Medicine, 216(10), 2254-2268. Becher, B., & Tugues, S. (2016). GM-CSF: From growth factor to central mediator of tissue inflammation. Immunity, 45(5), 963-973. Sonderegger, I., & Strobl, B. (2015). GM-CSF and its receptors in human monocytic cells. Frontiers in Immunology, 6, 1-10. Hamilton, J. A., & Achuthan, A. (2013). Colony stimulating factors and myeloid cell biology in health and disease. Trends in Immunology, 34(2), 81-89. |
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