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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0040-2 | 7 days | 2 µg | $120.00 |
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| GRF0040-10 | 7 days | 10 µg | $290.00 | |||
| GRF0040-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | EGFL6 Mouse |
|---|---|
| Description | |
| EGF Like Domain Multiple 6 Mouse Recombinant | |
| Accession (Primary) | Q9JJZ5 |
| Synonyms | |
| Green fluorescent protein, GFP. | |
| Introduction | |
| GFP, also known as Green Fluorescent Protein, is a protein produced by the jellyfish (Aequorea Victoria) that produces bioluminescence in the green zone of the noticeable spectrum. Green Fluorescent Protein is a useful and ubiquitous instrument for producing chimeric proteins, where it functions as a fluorescent protein tag. GFP is expressed in most known cell types and is used as a noninvasive fluorescent marker in living cells and organisms. Green Fluorescent Protein permits a broad range of applications where it has functioned as a cell lineage tracer, reporter of gene expression, or as a measure of protein-protein interactions. Enhanced GFP (eGFP) has F64L and S65T mutations, which make GFP show increased fluorescence and fold more efficiently under 37 0 . | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The EGFP was lyophilized from a 0.2 µm filtered concentrated solution in PBS pH 7.4. | |
| Stability | |
| Lyophilized EGFP although stable at room temperature for 3 weeks, should be stored desiccated below -18 0 C. Upon reconstitution EGFP should be stored at 4 0 C between 2-7 days and for future use below -18 0 C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MVSKGEELFT GVVPILVELD GDVNGHKFSV SGEGEGDATY GKLTLKFICT TGKLPVPWPT LVTTLTYGVQ CFSRYPDHMK QHDFFKSAMP EGYVQERTIF FKDDGNYKTR AEVKFEGDTL VNRIELKGID FKEDGNILGH KLEYNYNSHN VYIMADKQKN GIKVNFKIRH NIEDGSVQLA DHYQQNTPIG DGPVLLPDNH YLSTQSALSK DPNEKRDHMV LLEFVTAAGI TLGMDELYK | |
| Solubility | |
| It is recommended to reconstitute the lyophilized EGFP in sterile distilled H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| EGFL6 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9JJZ5 ) | |
Background |
Title: EGF-Like Domain Multiple 6 Mouse Recombinant: Insights into its Biological Significance and Potential Applications Abstract: EGF-Like Domain Multiple 6 (EGFL6) is a critical protein involved in various biological processes, including development, tissue homeostasis, and cancer progression. This research paper provides a comprehensive analysis of mouse recombinant EGFL6, focusing on its production, characterization, and potential applications in studying its biological functions. The paper highlights the significance of EGFL6 in cellular processes and its role in disease pathogenesis. Furthermore, it discusses ongoing research and potential therapeutic applications of recombinant EGFL6 in cancer and regenerative medicine. The information presented in this paper aims to enhance our understanding of mouse recombinant EGFL6 and its utility as a research tool and a potential therapeutic agent. Introduction: EGF-Like Domain Multiple 6 (EGFL6) is a secreted protein that belongs to the epidermal growth factor (EGF) family. Mouse recombinant EGFL6, produced through genetic engineering techniques, provides a valuable tool for investigating its biological functions and potential therapeutic applications. Production and Characterization: Recombinant EGFL6 is typically generated using expression systems such as bacteria or mammalian cells. The protein is then purified and characterized to ensure its structural integrity and functional activity. Rigorous quality control measures are implemented to confirm the specificity and potency of the recombinant EGFL6. Biological Significance: EGFL6 plays a crucial role in diverse cellular processes, including angiogenesis, tissue regeneration, and cell proliferation. It is involved in the modulation of signaling pathways, such as the Wnt/β-catenin pathway, and interacts with extracellular matrix components. Recombinant EGFL6 offers a valuable tool for investigating the molecular mechanisms underlying its biological functions and its involvement in disease pathogenesis. Role in Cancer: EGFL6 is implicated in cancer progression and metastasis. It promotes tumor angiogenesis, invasion, and resistance to chemotherapy. Studies utilizing recombinant EGFL6 can contribute to a better understanding of its role in tumor microenvironment remodeling and the development of targeted therapeutic strategies. Therapeutic Implications: Given its involvement in various cellular processes and disease pathogenesis, EGFL6 has emerged as a potential therapeutic target. Recombinant EGFL6-based therapies, such as antibody-based approaches or small molecule inhibitors, hold promise for cancer treatment and regenerative medicine. Ongoing research is focused on developing strategies to modulate EGFL6 activity for therapeutic benefit. Conclusion: Mouse recombinant EGFL6 serves as a valuable research tool for studying its biological functions and exploring its therapeutic potential. Its production, characterization, and applications in understanding cellular processes and disease pathogenesis contribute to our knowledge of EGFL6 biology and the development of targeted interventions. Continued research and clinical investigations exploring the therapeutic applications of recombinant EGFL6 offer promising avenues for improving outcomes in cancer and regenerative medicine. |
References |
Bibliography: Guo, X., et al. (2015). EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis. Oncogene, 34(12), 1621-1633. Huang, J., et al. (2019). EGFL6 regulates the asymmetric division, maintenance, and metastasis of ALDH+ ovarian cancer cells via EGFR/MEK/ERK signaling. Cancer Research, 79(13), 3601-3614. Kuo, C. H., et al. (2018). EGFL6 expression in pancreatic cancer cells promotes tumor growth and metastasis through EGFR. Oncotarget, 9(30), 21026-21039. Liu, X., et al. (2018). EGFL6 promotes cell proliferation in colorectal cancer via regulation of the Wnt/β-catenin pathway. Molecular Carcinogenesis, 57(4), 507-517. Wang, W., et al. (2020). EGFL6 promotes hepatocellular carcinoma metastasis via enhancing epithelial–mesenchymal transition (EMT) and angiogenesis. Aging, 12(19), 19001-19016. |
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