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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0051-2 | 7 days | 2 µg | $120.00 |
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| GRF0051-10 | 7 days | 10 µg | $290.00 | |||
| GRF0051-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | EPOR Human |
|---|---|
| Description | |
| Erythropoietin Receptor Human Recombinant | |
| Accession (Primary) | P19235 |
| Synonyms | |
| EPO-R, EPOR, Erythropoietin Receptor. | |
| Introduction | |
| Erythropoietin receptor, also known as EPOR arbitrates erythropoietin-induced erythroblast proliferation as well as differentiation. During EPO binding, EPOR activates Jak2 tyrosine kinase which activates various intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. Furthermore, stimulated EPOR has a function in erythroid cell survival. Mutations in EPOR may possibly produce erythroleukemia and familial erythrocytosis. In addition, dysregulation of EPOR can affect on the growth of selected tumors. | |
| Source | |
| Sf9, Baculovirus cells. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| EPOR protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by analysis by SDS-PAGE. | |
| Amino acid sequence | |
| APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDP HHHH HH. | |
| Biological Activity | |
| Measured by its ability to inhibit EPO dependent proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect less or equal to 70ng/ml. | |
| Precautions | |
| EPOR Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P19235 ) | |
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ADMEbio Team
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