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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0053-10 | 7 days | 10 µg | $120.00 |
Select product before adding to cart
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| GRF0053-50 | 7 days | 50 µg | $290.00 | |||
| GRF0053-1 | 7 days | 1 mg | $2,160.00 |
Product Overview | |
| Name | FGF 1 Human |
|---|---|
| Description | |
| Fibroblast Growth Factor-Acidic Human Recombinant | |
| Accession (Primary) | P05230 |
| Synonyms | |
| HBGF-1, ECGF-beta, FIBP, FGFIBP, FIBP-1, ECGF, ECGFA, GLIO703, FGF1, FGF-a. | |
| Introduction | |
| Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. | |
| Source | |
| Baculovirus. | |
| Physical Appearance | |
| Sterile Filtered liquid formulation. | |
| Formulation | |
| The sterile protein solution (1.8mg/ml) contains 20mM Tris HCl pH=7.9, 100mM KCl, 0.2mM DTT and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids as determined and was found to be Met-Phe-Asn-Leu-Pro. | |
| Biological Activity | |
| The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <10 ng/ml, corresponding to a specific activity of 100,000IU/mg. | |
| Precautions | |
| FGF 1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P05230 ) | |
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ADMEbio Team
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ADMEbio Team
