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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0108-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| GRF0108-10 | 7 days | 10 µg | $290.00 | |||
| GRF0108-1 | 7 days | 1 mg | $5,616.00 |
Product Overview | |
| Name | G CSF Human |
|---|---|
| Description | |
| Granulocyte-Colony Stimulating Factor Human Recombinant | |
| Accession (Primary) | P09919 |
| Synonyms | |
| CSF-3, MGI-1G, GM-CSF beta, Pluripoietin, Filgrastim, Lenograstim, G-CSF, MGC45931, GCSF. | |
| Introduction | |
| Granulocyte Colony Stimulating Factor is a growth factor and/or cytokine produced by the endothelium, macrophages and a number of other immune cells. GCSF stimulates the bone marrow to produce granulocytes and also to stimulate the survival, proliferation, differentiation and function of neutrophil granulocyte progenator cells and mature neutrophils. | |
| Source | |
| Chinese Hamster Ovary Cells (CHO). | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| G-CSF was lyophilized from a concentrated (1mg/ml) solution containing 10mM Hydrochloric Acid pH=6.5, 0.4mg tween 20, 100mg mannitol, 160mg L-arginine, 40mg phenylalanine and 4mg methionine. | |
| Stability | |
| Lyophilized Granulocyte Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution G-CSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP. | |
| Biological Activity | |
| The ED 50 , calculated by the dose-dependant proliferation of murine NFS-60 indicator cells (measured by 3 H-thymidine uptake) is < 0.07 ng/ml, corresponding to a Specific Activity of 1.27 x 10 8 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Granulocyte Colony Stimulating Factor in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| G CSF Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P09919 ) | |
References |
Title :Contribution of an Aged Microenvironment to Aging-Associated Myeloproliferative Disease. Publication :Vas V, Wandhoff C, Dörr K, Niebel A, Geiger H (2012) Contribution of an Aged Microenvironment to Aging-Associated Myeloproliferative Disease. PLoS ONE 7(2): e31523. doi:10.1371/journal.pone.0031523 Link : G CSF prospec publication |
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