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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0141-2 | 7 days | 2 µg | $120.00 |
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| GRF0141-10 | 7 days | 10 µg | $290.00 | |||
| GRF0141-1 | 7 days | 1 mg | $4,680.00 |
Product Overview | |
| Name | GM CSF Monkey |
|---|---|
| Description | |
| Granulocyte Macrophage-Colony Stimulating Factor Rhesus Macaque Recombinant | |
| Accession (Primary) | Q0MUT8 |
| Synonyms | |
| CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, CSF2, GMCSF | |
| Introduction | |
| GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GM-CSF Mouse was lyophilized with no additives. | |
| Stability | |
| Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GM-CSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Thr-Arg. | |
| Biological Activity | |
| The ED50 as determined by the dose-dependant stimulation of the proliferation of murine FDC-P1 cell line is < 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 20mM AcOH (acetic Acid) not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| 5. Title :Pre-clinical Evaluation of a CEA DNA Prime/protein Boost Vaccination Strategy Against Colorectal Cancer. Publication :Article first published online: 21 JUN 2007 DOI:10.1111/j.1365-3083.2007.01945.x Scandinavian Journal of Immunology Volume 66, Issue 1, pages 43–51, July 2007 Link : Granulocyte Macrophage-Colony Stimulating Factor prospec publication 6. Title :Intranasal Granulocyte-Macrophage Colony-Stimulating Factor Reduces the Aspergillus Burden in an Immunosuppressed Murine Model of Pulmonary Aspergillosis. Publication : First published November 2007, doi: 10.1128/?AAC.00760-07 Antimicrob. Agents Chemother. February 2008 vol. 52 no. 2 716-718 Link: Granulocyte Macrophage-Colony Stimulating Factor Mouse publication 7. Title: O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma . Publications: Clinical & Experimental Immunology 143.1 (2006): 139-149. Link: GMCSF Protein prospec publication 8. Title: Novel Functions of Herbal Medicines in DendriticCells: Role of Amomi Semen in Tumor Immunity Publications: Microbiology and immunology 51.11 (2007): 1121-1133. Link: GM-CSF prospec publication 9. Title: The Herbal Medicine Compound Falcarindiol from Notopterygii Rhizoma Suppresses Dendritic Cell Maturation Publication: Journal of Pharmacology and Experimental Therapeutics 333.3 (2010): 954-960. Link: CSF-2 Protein prospec publication | |
| Protein content | |
| GM-CSF quantitation was carried out by two independent methods 1. UV spectroscopy at 280 nm using the absorbency value of 0.765 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of GM-CSF as a Reference Standard. | |
| Precautions | |
| GM CSF Monkey is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q0MUT8 ) | |
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