Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0142-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
|
||
| GRF0142-20 | 7 days | 20 µg | $290.00 | |||
| GRF0142-1 | 7 days | 1 mg | $4,680.00 |
Product Overview | |
| Name | GM CSF Mouse |
|---|---|
| Description | |
| Granulocyte Macrophage-Colony Stimulating Factor Mouse Recombinant | |
| Accession (Primary) | P01587 |
| Synonyms | |
| CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim. | |
| Introduction | |
| GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GM-CSF Rat was lyophilized with no additives. | |
| Stability | |
| Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GMCSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 96.0% as determined by: (a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK. | |
| Biological Activity | |
| The ED 50 as calculated by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is less than 0.01ng/ml, corresponding to a specific activity of > 1×10 8 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| GM CSF Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P01587 ) | |
References |
5. Title :Pre-clinical Evaluation of a CEA DNA Prime/protein Boost Vaccination Strategy Against Colorectal Cancer. Publication :Article first published online: 21 JUN 2007 DOI:10.1111/j.1365-3083.2007.01945.x Scandinavian Journal of Immunology Volume 66, Issue 1, pages 43–51, July 2007 Link : Granulocyte Macrophage-Colony Stimulating Factor prospec publication 6. Title :Intranasal Granulocyte-Macrophage Colony-Stimulating Factor Reduces the Aspergillus Burden in an Immunosuppressed Murine Model of Pulmonary Aspergillosis. Publication : First published November 2007, doi: 10.1128/?AAC.00760-07 Antimicrob. Agents Chemother. February 2008 vol. 52 no. 2 716-718 Link: Granulocyte Macrophage-Colony Stimulating Factor Mouse publication 7. Title: O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma . Publications: Clinical & Experimental Immunology 143.1 (2006): 139-149. Link: GMCSF Protein prospec publication 8. Title: Novel Functions of Herbal Medicines in DendriticCells: Role of Amomi Semen in Tumor Immunity Publications: Microbiology and immunology 51.11 (2007): 1121-1133. Link: GM-CSF prospec publication 9. Title: The Herbal Medicine Compound Falcarindiol from Notopterygii Rhizoma Suppresses Dendritic Cell Maturation Publication: Journal of Pharmacology and Experimental Therapeutics 333.3 (2010): 954-960. Link: CSF-2 Protein prospec publication |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
