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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0171-10 | 7 days | 10 µg | $120.00 |
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| GRF0171-50 | 7 days | 50 µg | $290.00 | |||
| GRF0171-1 | 7 days | 1 mg | $3,040.00 |
Product Overview | |
| Name | IGF1 Rabbit |
|---|---|
| Description | |
| Insulin-Like Growth Factor 1 Rabbit Recombinant | |
| Accession (Primary) | Q95222 |
| Synonyms | |
| Somatomedin C, IGF-I, IGFIA, IGF1. | |
| Introduction | |
| The somatomedins, or IGFs, comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of GH. Early studies showed that GH did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003). | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized with a 0.2 µm filtered concentrated solution in 20mM PBS, pH 7.0. | |
| Stability | |
| Lyophilized IGF-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFI should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKSA. | |
| Biological Activity | |
| The ED 50 as determined by a cell proliferation assay using FDC-P1 cells is less than 2.0ng/ml, corresponding to a specific activity of > 500,000units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IGF1 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title :Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo. Publication : Published online before print March 17, 2009, doi: 10.1677/ERC-08-0219 Endocr Relat Cancer June 1, 2009 16 415-428 . Link : IGF1 Rat prospec publication | |
| Precautions | |
| IGF1 Rabbit is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q95222 ) | |
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