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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0172-10 | 7 days | 10 µg | $120.00 |
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| GRF0172-50 | 7 days | 50 µg | $290.00 | |||
| GRF0172-1 | 7 days | 1 mg | $2,160.00 |
Product Overview | |
| Name | IGF1 Rat |
|---|---|
| Description | |
| IGF-1 Rat Recombinant | |
| Accession (Primary) | P08025 |
| Synonyms | |
| Somatomedin-A, IGF2, INSIGF, pp9974, C11orf43, FLJ22066, FLJ44734. | |
| Introduction | |
| IGF-2 is a member of the INS family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a sterile filtered solution containing 0.1 % trifluoroacetic acid (TFA). | |
| Stability | |
| Lyophilized IGF-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFII should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE. | |
| Biological Activity | |
| The activity is determined by the dose dependent proliferation of FDC-P1 cells and is typically 8.39ng/mL corresponding to a specific activity of 1.2x10 5 units/mg.. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IGF2 in sterile 18MΩ-cm H2O at a concentration of 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title: Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP Publications: Nucleoli Leading to Potentially Invalid Conclusions of Its Function. PLoS ONE 10.2 (2015): e0114813. Link: IGF2 prospec publication | |
| Precautions | |
| IGF1 Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P08025 ) | |
References |
Title :Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo. Publication : Published online before print March 17, 2009, doi: 10.1677/ERC-08-0219 Endocr Relat Cancer June 1, 2009 16 415-428 . Link : IGF1 Rat prospec publication |
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