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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0215-200 | 7 days | 200 µg | $120.00 |
Select product before adding to cart
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| GRF0215-1 | 7 days | 1 mg | $290.00 | |||
| GRF0215-5 | 7 days | 5 mg | $720.00 |
Product Overview | |
| Name | Leptin Rat |
|---|---|
| Description | |
| Leptin Rat Recombinant | |
| Accession (Primary) | P50596 |
| Synonyms | |
| OB Protein, Obesity Protein, OBS, Obesity factor, Leptin Receptor. | |
| Introduction | |
| Leptin Receptor is a part of the gp130 family of cytokine receptors that stimulate gene transcription by activating cytosolic STAT proteins. Leptin Receptor plays a role in the regulation of fat metabolism and in novel hematopoietic pathway that is obligatory for normal lymphopoiesis. Leptin Receptorparticipates in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus.Leptin Receptoraffectsspecifically on T lymphocyte responses. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution at a concentration of 0.4 mg/ml. | |
| Formulation | |
| The protein was filter sterilized and stored at 4°C (0.2 to 0.5 mg/ml) solution of Tris-HCl buffer, pH 9.0 with 150mM NaCl. | |
| Stability | |
| Sterile solutions at 0.5mg/ml or less are stable at 4°C for several months. | |
| Purity | |
| Greater than 99.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Ile-Asp-Val-Asn-Ile Biological ActivityBiological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio. | |
| Protein content | |
| Protein quantitation was carried out by two independent methods 1. UV spectroscopy at 280 nm using the absorbency value of 2.45 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of Leptin Binding Domain as a Reference Standard. | |
| Precautions | |
| Leptin Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P50596 ) | |
References |
1.Title:Expression of Hypothalamic KiSS-1 System and Rescue of Defective Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats. Publication: doi: 10.2337/db05-1584 Diabetes September 2006 vol. 55 no. 9 2602-2610 Link: Leptin prospec publication 2.Title:Desensitization of responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Publication:Am J Physiol Endocrinol Metab 294: E1088–E1096, 2008.294: E1088–E1096, 2008. First published April 15, 2008; doi:10.1152/ajpendo.90240.2008. Link: Leptin Rat protein prospec publication 3.Title:p38 MAPK and LXR? mediate leptin effect on SREBP-1c expression in hepatic stellate cells (short title: Leptin effect on SREBP-1c expression) . Publication: Link: OBS Rat prospec publication 4.Title:Neuroprotection by leptin in a rat model of permanent cerebral ischemia: effects on STAT3 phosphorylation in discrete cells of the brain. Publication:Citation: Cell Death and Disease (2011) 2, e238; doi:10.1038/cddis.2011.125 Published online 8 December 2011. Link: Obesity Protein prospec publication 5.Title: The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Publication: Endocrinology 150.11 (2009): 5016-5026. Link Obesity Protein Rat prospec publication |
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ADMEbio Team
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