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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0350-1 | 7 days | 1 µg | $120.00 |
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| GRF0350-5 | 7 days | 5 µg | $290.00 | |||
| GRF0350-50 | 7 days | 50 µg | $1,920.00 |
Product Overview | |
| Name | Prolactin Mouse, His |
|---|---|
| Description | |
| Prolactin Mouse Recombinant, His Tag | |
| Accession (Primary) | P06879 |
| Synonyms | |
| Mammotropin, Luteotropic hormone, Luteotropin, PRL. | |
| Introduction | |
| Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (1mg/ml) solution with 0.02-0.03% NaHCO 3 . | |
| Stability | |
| Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prl should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 99.0% as determined by: (a) Gel filtration analysis. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Thr-Pro-Val-Cys-Pro. | |
| Biological Activity | |
| Is fully biologically active as evidenced by inducing proliferation of Nb2 cells. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Prolactin in sterile 18MΩ-cm H 2 O or 0.4% NaHCO 3 adjusted to pH 8-9, not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| 1. Title :Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets. Publication :Published online before print December 18, 2008, doi: 10.1210/en.2008-1318 Endocrinology April 1, 2009 vol. 150 no. 4 1646-1653 . Link : Prolactin prospec publication 2. Title :ISLET ENDOTHELIAL CELLS AND PANCREATIC ?-CELL PROLIFERATION: STUDIES IN VITRO AND DURING PREGNANCY IN ADULT RATS. Publication :Endocrinology. First published January 26, 2006 as doi:10.1210/en.2005-0997. Link : Prolactin Ovine prospec publication 3. Title :Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets. Publication :Endocrinology. First published ahead of print December 18, 2008 as doi:10.1210/en.2008-1318. Link : Prolactin Protein prospec publication 4. Title: Islet Endothelial Cells and Pancreatic -Cell Proliferation: Studies in Vitro and during Pregnancy in Adult Rats. Publication: Published online before print January26, 2006, doi: 10.1210/en.2005-0997 Endocrinology May 1 , 2006 vol. 147no. 52315-2324. Link: http://endo.endojournals.org/content/147/5/2315.full.pdf+htm l | |
| Protein content | |
| Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.93 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC DNAman computer analysis program of protein sequences. | |
| Precautions | |
| Prolactin Mouse, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P06879 ) | |
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