Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0369-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
|
||
| GRF0369-10 | 7 days | 10 µg | $290.00 | |||
| GRF0369-1 | 7 days | 1 mg | $3,456.00 |
Product Overview | |
| Name | SCF Human |
|---|---|
| Description | |
| Stem Cell Factor Human Recombinant | |
| Accession (Primary) | P21583 |
| Synonyms | |
| Kit ligand Precursor, C-kit ligand, SCF, Mast cell growth factor, MGF, SF, KL-1, Kitl, DKFZp686F2250. | |
| Introduction | |
| Stem cell factor / KIT ligand (SCF) is a cytokine which binds CD117(c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases. SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E (burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid). | |
| Source | |
| HEK. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| SCF was lyophilized from a 0.2 µm filtered solution (1mg/ml) containing 1xPBS. | |
| Stability | |
| Lyophilized SCF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SCF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as obsereved by SDS-PAGE. | |
| Biological Activity | |
| The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line). The EC 50 is 15.25ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized SCF in sterile PBS containing 0.1% endotoxin-free recombinant HSA. | |
| Precautions | |
| SCF Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P21583 ) | |
References |
1. Title :Direct binding of Cbl to Y568 and Y936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Publication :Biochemical Journal Immediate Publication. Published on 19 Jun 2006 as manuscript BJ20060464. Link : SCF prospec publication 2. Title :The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction. Publication : March 5, 2009, doi: 10.1074/jbc.M808058200 April 24, 2009 The Journal of Biological Chemistry, 284, 11039-11047. Link : SCF Human prospec publication 3. Title :Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase. Publication :First Published on October 28, 2010, doi: 10.1074/jbc.M110.173526 January 7, 2011 The Journal of Biological Chemistry, 286, 480-490. Link : SCF Protein prospec publication 4. Title: Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit Publications: Journal of Biological Chemistry 283.41 (2008): 27444-27451. Link: Stem Cell Factor prospec publication |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
