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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0378-2 | 7 days | 2 µg | $120.00 |
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| GRF0378-10 | 7 days | 10 µg | $290.00 | |||
| GRF0378-0.1 | 7 days | 0.1 mg | $1,920.00 |
Product Overview | |
| Name | sRANKL (158-316) Mouse |
|---|---|
| Description | |
| Soluble RANK Ligand (158-316 a.a) Mouse Recombinant | |
| Accession (Primary) | Q3TWY5 |
| Synonyms | |
| Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related activation-induced cytokine, OPGL, ODF, Osteoclast differentiation factor, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa B ligand, RANKL, Osteoprotegerin ligand, CD254 antigen, sRANKL, sOdf, hRANKL2. | |
| Introduction | |
| RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (1mg/ml) solution containing 10mM Sodium phosphate, pH-7.5. | |
| Stability | |
| Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by analysis by SDS-PAGE. | |
| Amino acid sequence | |
| EKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID. | |
| Biological Activity | |
| The activity of RAW-Blue was measured to be 38.8 ng/ml, corresponding to a specific activity of 2.6x10 4 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized sRANKL in sterile 18MΩ-cm H2O at a concentration of 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| 1. Title :Cathepsin K Expression and Activity in Canine Osteosarcoma. Publication : Article first published online: 15 DEC 2011 DOI:10.1111/j.1939-1676.2011.00834.x Copyright © 2011 by the American College of Veterinary Internal Medicine. Link : sRANKL prospec publication 2.Title : Grape Seed Procyanidin Reversal of P-glycoprotein Associated Multi-Drug Resistance via Down-regulation of NF-?B and MAPK/ERK Mediated YB-1 Activity in A2780/T Cells Publication : DOI: 10.1371/journal.pone.0071071, August 15, 2013 Link : RANK Ligand Soluble prospec publication | |
| Precautions | |
| sRANKL (158-316) Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q3TWY5 ) | |
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