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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List |
|---|
Product Overview | |
| Name | GM CSF Human, HEK |
|---|---|
| Description | |
| Granulocyte Macrophage-Colony Stimulating Factor Human Recombinant, HEK | |
| Accession (Primary) | P04141 |
| Synonyms | |
| GM2 Ganglioside Activator, Cerebroside Sulfate Activator Protein, Sphingolipid Activator Protein 3, GM2-AP, SAP-3, GM2 Ganglioside Activator Protein, Shingolipid Activator Protein 3, GM2A. | |
| Introduction | |
| GM2 Ganglioside Activator Pseudogene 1 (GM2AP1) is a small glycolipid transport protein which functions as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, along with GM2AP1, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2AP1 protein is localized in lysosomes. GM2AP1 participates in lipid metabolism. GM2AP1 protein forms a large binding pocket for a number of single chain phospholipids and fatty acids. GM2AP1 displays calcium-independent phospholipase activity. GM2AP1 stimulates ganglioside GM2 degradation by presenting GM2 to beta-hexosaminidase A. GM2AP1 gene mutations result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GM2AP1 was filtered (0.4 µm) and lyophilized from 0.5mg/ml in 0.05M Tris buffer and 0.1M NaCl, pH 8.0. | |
| Stability | |
| Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MKHHHHHHA S FSWDNCDEGK DPAVIRSLTL EPDPIIVPGN VTLSVMGSTS VPLSSPLKVD LVLEKEVAGL WIKIPCTDYI GSCTFEHFCD VLDMLIPTGE PCPEPLRTYG LPCHCPFKEG TYSLPKSEFV VPDLELPSWL TTGNYRIESV LSSSGKRLGC IKIAASLKGI. | |
| Solubility | |
| It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. GM2AP1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. | |
| Precautions | |
| GM CSF Human, HEK is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P04141 ) | |
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ADMEbio Team
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