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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0452-10 | 7 days | 10 µg | $120.00 |
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| GRF0452-50 | 7 days | 50 µg | $290.00 | |||
| GRF0452-1 | 7 days | 1 mg | $3,360.00 |
Product Overview | |
| Name | Leptin qA Ovine |
|---|---|
| Description | |
| Leptin Antagonist Quadruple Mutant Ovine Recombinant | |
| Synonyms | |
| OB Protein, Obesity Protein, OBS, Obesity factor. | |
| Introduction | |
| A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3. | |
| Stability | |
| Lyophilized Rat Leptin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat Leptin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 99.0% as determined by: (a) Analysis by Gel-Filtration. (b) Analysis by SDS-PAGE. | |
| Biological Activity | |
| Pegylated Rat Leptin is capable of stimulatng proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Its in vitro activity is only slightly lower than the non-pegylated antagonist but in vivo it has profound weight reducing effect (as compared to the non-pegylated leptin), resulting mainly from reduced food intake. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized pegylated Rat Leptin in sterile 0.4% NaHCO3 adjusted to pH-8.5, not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| Leptin qA Ovine is for research use only and not for use in diagnostic or therapeutic procedures. | |
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ADMEbio Team
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