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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0453-20 | 7 days | 20 µg | $200.00 |
Select product before adding to cart
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| GRF0453-100 | 7 days | 100 µg | $500.00 | |||
| GRF0453-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | Leptin Rat, PEG |
|---|---|
| Description | |
| Pegylated Rat Leptin Recombinant | |
| Accession (Primary) | P50596 |
| Synonyms | |
| OB Protein, Obesity Protein, OBS, Obesity factor, Leptin Receptor. | |
| Introduction | |
| Leptin Receptor is a part of the gp130 family of cytokine receptors that stimulate gene transcription by activating cytosolic STAT proteins. Leptin Receptor plays a role in the regulation of fat metabolism and in novel hematopoietic pathway that is obligatory for normal lymphopoiesis. Leptin Receptorparticipates in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus.Leptin Receptoraffectsspecifically on T lymphocyte responses. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (0.2-0.5mg/ml) solution of Tris-HCl buffer, pH 9.0 with 150 mM NaCl and 10-fold (w/w) excess of glycine. | |
| Stability | |
| Lyophilized Leptin Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Leptin Receptor should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 99.0% as determined by: (a) Gel filtration analysis. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Ile-Asp-Val-Asn-Ile. | |
| Biological Activity | |
| Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Leptin Receptor in sterile 18MΩ-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Protein content | |
| Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 2.45 as the extinction coefficient for a 0.1% (1mg/ml) solution at pH 9.0. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). | |
| Precautions | |
| Leptin Rat, PEG is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P50596 ) | |
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ADMEbio Team
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