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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0176-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| GRF0176-20 | 7 days | 20 µg | $290.00 | |||
| GRF0176-1 | 7 days | 1 mg | $6,240.00 |
Product Overview | |
| Name | IGFBP 4 Human |
|---|---|
| Description | |
| Insulin-Like Growth Factor Binding Protein-4 Human | |
| Accession (Primary) | P22692 |
| Synonyms | |
| IGFBP-5, IBP-5, IGF-binding protein 5. | |
| Introduction | |
| IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10mM sodium Citrate pH-3. | |
| Stability | |
| Lyophilized IBP5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP 5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE. | |
| Biological Activity | |
| The ED 50 , calculated by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is < 0.4 µg/ml, corresponding to a specific activity of > 2500 IU/mg in the presence of 15ng/ml of rHuIGF-II. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-5 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title :Effects of Dietary Carbohydrate Modification in Persons with the Metabolic Syndrome - A Transcriptomics Approach in Adipose Tissue Publication :Department of Clinical Nutrition, Food and Health Research Centre Institute of Public Health and Clinical Nutrition Faculty of Health Sciences University of Eastern Finland Kuopio 2010 Link : IGFBP 5 prospec publication | |
| Precautions | |
| IGFBP 4 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P22692 ) | |
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