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![[KD]Phospho-Presenilin 1 (Ser310) Rabbit mAb ABZ4707](http://img.admebio.com/products/SEAC100001/20260405/ABZ4707-KD.jpg)
![[KD]Phospho-Presenilin 1 (Ser310) Rabbit mAb ABZ4707](http://img.admebio.com/products/SEAC100001/20260405/ABZ4707-WB-1.jpg)
![[KD]Phospho-Presenilin 1 (Ser310) Rabbit mAb ABZ4707](http://img.admebio.com/products_thumb/SEAC100001/20260405/ABZ4707-KD.jpg)
![[KD]Phospho-Presenilin 1 (Ser310) Rabbit mAb ABZ4707](http://img.admebio.com/products_thumb/SEAC100001/20260405/ABZ4707-WB-1.jpg)
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4707-100 | 2 weeks | 100 µL | $499.00 |
Select product before adding to cart
|
||
| ABZ4707-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | [KD]Phospho-Presenilin 1 (Ser310) Rabbit mAb |
|---|---|
| Accession (Primary) | P49768 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human |
| Calculated MW | |
| Calculated MW: 53 kDa; Observed MW: 22 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Phosphorylated | |
| Form | |
| Liquid | |
| Background | |
| Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. | |
Target Information: ( P49768 ) | |
| Name | PSEN1 |
| Gene ID | 5663 |
| Other Names | |
| AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3 | |
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ADMEbio Team
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