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[KO]LAT Rabbit mAb

Catalog #: ABZ4721
Application: WB, FC, IHC-P
Uniprot Id: O43561
Reactivity: Human
Isotype: IgG

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Western blot analysis of LAT in HT1080(WT) and LAT-Knockout HT1080(KO) using LAT antibody.
Western blot analysis of LAT in U2OS lysates using LAT antibody.
Immunohistochemistry analysis of paraffin-embedded Human tonsil using LAT antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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Datasheet
Citations
Reviews

Species Reactivity
Product Overview
Name	[KO]LAT Rabbit mAb
Accession (Primary)	O43561
Host Species	Rabbit
Clonality	Monoclonal
Isotype	IgG
Reacts With	Human
Calculated MW
Calculated MW: 28 kDa; Observed MW: 36 kDa
Buffer System
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Recommended Dilution
WB-1:500-1:1000; IHC-1:50-1:100; FC-1:100
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Background
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Target Information: ( O43561 )
Name	LAT
Gene ID	27040
Other Names
LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

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