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[KO]4E BP1 Rabbit mAb

Catalog #: ABZ4654
Application: WB, IF, FC, IP, ICC, IHC-P
Uniprot Id: Q13541
Reactivity: Human, Mouse, Rat
Isotype: IgG

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Western blot analysis of 4E BP1 in HeLa(WT) and 4E BP1-Knockout HeLa(KO) using 4E BP1 antibody.
Western blot analysis of eIF4EBP1 in mouse heart lysates using 4E BP1 antibody.
Western blot analysis of eIF4EBP1 in Jurkat, C6, CHO-K1 lysates using eIF4EBP1 antibody.
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using eIF4EBP1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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Datasheet
Citations
Reviews

Species Reactivity
Product Overview
Name	[KO]4E BP1 Rabbit mAb
Accession (Primary)	Q13541
Host Species	Rabbit
Clonality	Monoclonal
Isotype	IgG
Reacts With	Human, Mouse, Rat
Calculated MW
Calculated MW: 13 kDa; Observed MW: 15-20 kDa
Buffer System
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Recommended Dilution
WB-1:500-1:1000; IHC-P-1:100-1:200; ICC/IF-1:200-1:500; FC-1:20-1:50; IP-1:20
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Background
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
Target Information: ( Q13541 )
Name	EIF4EBP1
Gene ID	1978
Other Names
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

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