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![[KO]Bcr Rabbit mAb ABZ4802](http://img.admebio.com/products/SEAC100001/20260405/ABZ4802-IHC-2.jpg)
![[KO]Bcr Rabbit mAb ABZ4802](http://img.admebio.com/products_thumb/SEAC100001/20260405/ABZ4802-IHC-2.jpg)
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4802-100 | 2 weeks | 100 µL | $499.00 |
Select product before adding to cart
|
||
| ABZ4802-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | [KO]Bcr Rabbit mAb |
|---|---|
| Accession (Primary) | P11274 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human |
| Calculated MW | |
| Calculated MW: 143 kDa; Observed MW: 160 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:1000-1:5000; IHC-P-1:50-1:100; ICC/IF-1:100-1:200 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] | |
Target Information: ( P11274 ) | |
| Name | BCR |
| Gene ID | 613 |
| Other Names | |
| ALL; CML; PHL; BCR1; D22S11; D22S662; bcr; BCR/ABL FUSION GENE; INCLUDED; | |
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ADMEbio Team
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