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![[KO]beta Dystroglycan Rabbit mAb ABZ4757](http://img.admebio.com/products/SEAC100001/20260405/ABZ4757-WB-1.jpg)
![[KO]beta Dystroglycan Rabbit mAb ABZ4757](http://img.admebio.com/products_thumb/SEAC100001/20260405/ABZ4757-WB-1.jpg)
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4757-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4757-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | [KO]beta Dystroglycan Rabbit mAb |
|---|---|
| Accession (Primary) | Q14118 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse |
| Calculated MW | |
| Calculated MW: 97 kDa; Observed MW: 42-44 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Dystroglycan, also known as DAG1 or DG, was originally isolated from skeletal muscle as an integral membrane component of the dystrophin-glycoprotein complex (DGC). In addition to skeletal muscle, dystroglycan is strongly expressed in heart and smooth muscle, as well as many non-muscle tissues including brain and peripheral nerve (PMID: 12556455). The dystroglycan is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Dystroglycan consists of two subunits (alpha and beta), which are translated from a single mRNA as a propeptide that is proteolytically cleaved into two noncovalently associated proteins (PMID: 16410545). Alpha-dystroglycan is a 156-kDa extracellular peripheral glycoprotein, while beta-dystroglycan is a 43-kDa transmembrane protein (PMID: 9858474). The 43-kDa beta-dystroglycan can be cleaved into a ~30-kDa form (PMID: 14678802; 18458097; 17255331). | |
Target Information: ( Q14118 ) | |
| Name | DAG1 |
| Gene ID | 1605 |
| Other Names | |
| A3a; DAG; AGRNR; 156DAG; MDDGA9; MDDGC7; MDDGC9; LGMDR16; DAG1; Beta DG; Alpha DG Beta dystroglycan | |
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