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[KO]Integrin alpha 5 Rabbit mAb

Catalog #: ABZ4742
Application: WB, IF, FC, IP, ICC, IHC-P
Uniprot Id: P08648
Reactivity: Human, Mouse, Rat
Isotype: IgG

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Western blot analysis of Integrin alpha 5 in HeLa(WT) and Integrin alpha 5-Knockout HeLa(KO) using Integrin alpha 5 antibody.
Western blot analysis of Integrin alpha 5 in K562, 3T3 lysates using Integrin alpha 5 antibody.
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Integrin alpha 5 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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	ABZ4742-20	2 weeks	20 µL	reduce add	$149.00	Add to Cart INQUIRE Select product before adding to cart

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Datasheet
Citations
Reviews

Species Reactivity
Product Overview
Name	[KO]Integrin alpha 5 Rabbit mAb
Accession (Primary)	P08648
Host Species	Rabbit
Clonality	Monoclonal
Isotype	IgG
Reacts With	Human, Mouse, Rat
Calculated MW
Calculated MW: 115 kDa; Observed MW: 150 kDa
Buffer System
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Recommended Dilution
WB-1:1000-1:5000; IHC-P-1:100-1:200; ICC/IF-1:20-1:50; FC-1:20; IP-1:10-1:100
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Background
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Target Information: ( P08648 )
Name	ITGA5
Gene ID	3678
Other Names
ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e

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