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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTP0058-100 | 7 days | 100 µg | $800.00 |
Select product before adding to cart
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| NTP0058-200 | 7 days | 200 µg | $1,400.00 | |||
| NTP0058-1 | 7 days | 1 mg | $3,200.00 |
Product Overview | |
| Name | Thyroglobulin Canine |
|---|---|
| Description | |
| Thyroglobulin Canine | |
| Accession (Primary) | P15881 |
| Synonyms | |
| Thyroglobulin, TGN, AITD3, TG. | |
| Source | |
| Mammalian cell line. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Thyroglobulin was lyophilized from PBS, pH 7.4 and 5.4 % sucrose. | |
| Stability | |
| Lyophilized Thyroglobulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thyroglobulin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Thyroglobulin in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Background | |
| Thyroglobulin, a glycoprotein primarily produced in the thyroid gland, stands at the center of thyroid hormone synthesis. Comprising a series of tyrosine residues, thyroglobulin serves as the scaffold upon which thyroid hormones are assembled. Beyond its pivotal role in thyroid physiology, thyroglobulin has garnered significant attention in the realm of thyroid disease diagnostics, offering valuable insights into thyroid function and disorders. This research delves into the intricacies of thyroglobulin human recombinant protein, exploring its biochemical properties, physiological significance, and its crucial applications in both clinical and research settings. Structural Complexity of Thyroglobulin: Thyroglobulin is a large, dimeric protein boasting an intricate structure composed of multiple domains. Within its structure lie tyrosine residues crucial for iodine incorporation, a process fundamental for thyroid hormone synthesis. Its size and complexity reflect the sophistication of thyroid hormone production, as thyroglobulin acts as a reservoir for thyroid hormones within the thyroid follicles. Physiological Significance in Thyroid Function: Thyroglobulin plays a central role in the synthesis of triiodothyronine (T3) and thyroxine (T4), the thyroid hormones essential for regulating metabolism and overall body homeostasis. During thyroid hormone synthesis, thyroglobulin is secreted into the follicular lumen, where it undergoes iodination and subsequent proteolysis, releasing T3 and T4. This process highlights the indispensable nature of thyroglobulin in thyroid hormone production, making it a key biomolecule in thyroid physiology. | |
| Precautions | |
| Thyroglobulin Canine is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P15881 ) | |
Background |
Thyroglobulin's presence in the bloodstream, typically at low levels, is crucial for post-thyroidectomy monitoring and diagnosing thyroid disorders. Elevated serum thyroglobulin levels often indicate thyroid tissue remnants or recurrence of thyroid cancer. Thyroglobulin assays, including those utilizing recombinant thyroglobulin protein, serve as invaluable tools in assessing the effectiveness of thyroid cancer treatments, aiding clinicians in disease management decisions. In the realm of thyroid research, recombinant thyroglobulin finds extensive use as a research tool. Scientists utilize it to study thyroid hormone synthesis mechanisms, exploring the intricacies of iodination, thyroglobulin proteolysis, and hormone release. Additionally, it serves as a model for investigating autoimmune thyroid diseases, aiding in the understanding of conditions like Hashimoto's thyroiditis and Graves' disease. Thyroglobulin human recombinant protein, with its multifaceted roles in thyroid hormone synthesis and disease diagnostics, stands as a testament to the complexity of thyroid physiology. Its structural intricacies and diagnostic significance underscore its pivotal position in the field of endocrinology. As our understanding of thyroid disorders deepens, thyroglobulin, both as a biological entity and a research tool, continues to illuminate the path towards effective diagnostic methods and therapeutic interventions, emphasizing its indispensable role in the intricate workings of the thyroid gland. |
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